CNS tumors, such as diffuse midline glioma (DMG), an inoperable and aggressive pediatric brain tumor, are notorious for evading treatment through their diverse cell populations, manipulating the immune system, and escaping therapeutic agents that can’t cross the blood-brain barrier (BBB). Current research focuses on developing new therapeutic strategies and medications to overcome these obstacles.

“Project DeLaRosa marks a significant milestone for our organization's brain cancer research-funding mission. Pediatric brain tumors, the leading cause of cancer-related deaths in children, demand urgent attention,” mentions Amber Barbach, founder and director of the GBMRO. “We are proud to support world-class research at Children's National Hospital, whose team ensures providers are equipped to improve pediatric healthcare now and into the future."

Led by Javad Nazarian, Ph.D., M.Sc. and its global DMG-ACT pre-clinical team, Project DeLaRosa will fund the NICO Myriad Biopsy System, suitable to precisely collect tumor samples from the brain stem. The research involves a novel longitudinal biopsy technique in a murine (mouse) model, which enables researchers to take multiple samples from the same tumor over time. This approach provides invaluable insights into how the cancer responds to treatment, potentially leading to developing new, more effective drug combinations and personalized treatment strategies for patients.

"Project DeLaRosa holds promise in transforming treatment for pediatric brain tumors like diffuse midline glioma (DMG) and could provide crucial insights into tumor response and the immune microenvironment," emphasizes Dr. Javad Nazarian. "We are grateful for the Glioblastoma Research Organization's support of our mission to advance innovative research that directly impacts patients and families.”

The organization’s latest initiative memorializes Bernie DeLaRosa, who passed away from glioblastoma, one of the deadliest CNS tumors. Bernie’s legacy continues through his wife, Cate DeLaRosa, and their family, honoring both him and Christine DeLaRosa, who each battled glioblastoma within a short span of time. Their family's ongoing dedication ensures that their fight continues on behalf of all those facing this devastating disease.