Unraveling the Connection: Understanding the Link Between Glioblastoma Brain Tumors and Epilepsy
Ricardo Jorge Komotar, MD, FAANS, FACS
Leading Glioblastoma (GBM) brain cancer expert gives an overview of the relationship between these deadly brain tumors and epilepsy.
Glioblastoma is a highly aggressive type of brain tumor that affects thousands of people around the world every year. It is well known for its rapid progression and poor prognosis, but did you know that Glioblastoma brain tumors and epilepsy are associated?
Glioblastoma has a significant impact on the normal functioning of the brain. As the tumor grows, it can invade and damage normal brain tissue, disrupting normal electrical activity in the brain. This disruption can result in seizures. In addition to the direct impact of the tumor on the brain, some patients with Glioblastoma may also develop epilepsy.
In this blog post, internationally recognized neurosurgeon and the Glioblastoma Research Organization (GBMRO) medical advisory board member, Dr. Ricardo Komotar, delves into the complex relationship between Glioblastoma brain tumors and epilepsy and what this means for patients affected by these conditions. With years of experience as co-director of Sylvester Comprehensive Cancer Center’s Brain Tumor Initiative and professor of Neurological Surgery at the University of Miami Miller School of Medicine, Dr. Komotar provides a general overview of this topic and provides a glimpse into promising developments in research for those affected by these conditions.
What is the connection between Glioblastoma brain tumors and epilepsy?
Glioblastoma (GBM) can sometimes present seizures and potentially long-term epilepsy.
Can you provide insight into brain cancer seizures life expectancy and what patients with both conditions can expect in terms of quality of life?
The treatment of the tumor and the treatment of epilepsy both involve neurooncologists. The combination can sometimes be challenging to manage and negatively impact the patient’s quality of life.
What are some short-term suggestions for patients with both conditions to stay active and keep their minds sharp?
Patients should walk as much as possible.
Are there any promising developments in research, whether it is clinical trials or treatments for patients with epilepsy and Glioblastoma?
The newer chemotherapy agents and treatment regimens are controlling the tumor better and, therefore, secondary epilepsy as well.
Does the location of the tumor in an individual’s brain influence the probability of developing seizures?
Yes, the location of the brain tumor can influence the probability of seizures. For example, temporal lobe tumors can cause seizures more frequently than other locations.
What does the future hold for epilepsy and Glioblastoma research?
We’re looking forward to the promise of therapies explicitly tailored to individual patients, targeting specific mutations to better control both diseases.
It is important to note that not all patients with Glioblastoma will develop epilepsy. The development of epilepsy in patients with Glioblastoma depends on several factors, including the location and size of the tumor, the extent of damage to normal brain tissue, and the type and intensity of treatment received. In conclusion, the link between Glioblastoma brain tumors and epilepsy is complex, as both conditions can be related to abnormal electrical activity in the brain and seizures.
Learn more about Glioblastoma symptoms and how to spot the signs of this deadly brain cancer tumor on our blog. If you’d like more GBM-related content from Dr. Komotar, read his recent blog post in partnership with leading neurosurgeons on the unmet challenges of Glioblastoma.
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Please note that the information provided on The Glioblastoma Research Organization is not a substitute for professional medical advice or treatment for specific medical conditions. You should not use this information to diagnose or treat a health problem without consulting a qualified healthcare provider.
Additional Resources:
Berntsson SG, Malmer B, Bondy ML, Qu M, Smits A. Tumor-associated epilepsy and glioma: are there common genetic pathways? Acta Oncol. 2009;48(7):955-63. doi: 10.1080/02841860903104145. PMID: 19639468; PMCID: PMC6436628.
Mayo Foundation for Medical Education and Research. Seizures. Mayo Clinic. Retrieved February 9, 2023, from https://www.mayoclinic.org/diseases-conditions/seizure/symptoms-causes/syc-20365711
